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Compounds

Cat No. Product Name Synonyms Targets
T68730 AVE1231 Potassium Channel
AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.
T3348 PIK-293 PIK293 PI3K
PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.
T16569 Praliciguat IW-1973 Others , Guanylate cyclase
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.
T19700 IBC 293 IBC293,IBC-293 GPR
IBC 293 is selective for GPR109B over niacin receptor GPR109A. IBC 293 is a highly selective agonist for GPR109B, a human orphan G-protein-coupled receptor expressed in adipocytes.
T6934 Pexmetinib ARRY-614 Tie-2 , p38 MAPK , Autophagy
Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.
T11076 Dooku1 Others
Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yod...
T5418 BAY-293 Raf , Ras
BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
T9018 JHU37160 JHU 37160 AChR
JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ...
T9019 JHU37152 JHU 37152 AChR
JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ...
T4967 NPS-2143 hydrochloride NPS-2143 HCL CaSR
NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist.
T2092 Amitifadine hydrochloride DOV-21947 hydrochloride,EB-1010 hydrochloride Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine
Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
T1730 NPS-2143 SB262470,NPS 2143,SB 262470A Calcium Channel , CaSR
NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.
T5345 V-9302 Others
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).
T27422 GNE-293 GNE293
GNE-293 is a potent and selective PI3Kδ inhibitor.
T15398 GNE-0946 Others
GNE-0946 is a potent and selective agonist of RORγ (EC50: 4 nM for HEK-293 cell).
T26621 AMP-579 RPR100579,RPR 100579,AMP 579,RPR-100579
AMP-579 is an adenosine A1 receptor agonist. AMP-579 also acts as a A2b-adenosine receptor agonist in human 293 cells and rabbit hearts.
T15404 GNE-6468 Others
GNE-6468 is a potent and selective agonist of RORγ(RORc) (EC50: 13 nM for HEK-293 cell).
T10271 AHR antagonist 4 Others
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects.
T25109 ARN-6039 ARN 6039,ARN6039
ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HE...
T41214 (S)-BAY-293 BAY 294,BAY 293 Negative Control Ras
(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.
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TargetMol