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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T68730 | AVE1231 | Potassium Channel | |
AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation. | |||
T3348 | PIK-293 | PIK293 | PI3K |
PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ. | |||
T16569 | Praliciguat | IW-1973 | Others , Guanylate cyclase |
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator. | |||
T19700 | IBC 293 | IBC293,IBC-293 | GPR |
IBC 293 is selective for GPR109B over niacin receptor GPR109A. IBC 293 is a highly selective agonist for GPR109B, a human orphan G-protein-coupled receptor expressed in adipocytes. | |||
T6934 | Pexmetinib | ARRY-614 | Tie-2 , p38 MAPK , Autophagy |
Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1. | |||
T11076 | Dooku1 | Others | |
Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yod... | |||
T5418 | BAY-293 | Raf , Ras | |
BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM). | |||
T9018 | JHU37160 | JHU 37160 | AChR |
JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ... | |||
T9019 | JHU37152 | JHU 37152 | AChR |
JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ... | |||
T4967 | NPS-2143 hydrochloride | NPS-2143 HCL | CaSR |
NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist. | |||
T2092 | Amitifadine hydrochloride | DOV-21947 hydrochloride,EB-1010 hydrochloride | Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine |
Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). | |||
T1730 | NPS-2143 | SB262470,NPS 2143,SB 262470A | Calcium Channel , CaSR |
NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor. | |||
T5345 | V-9302 | Others | |
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM). | |||
T27422 | GNE-293 | GNE293 | |
GNE-293 is a potent and selective PI3Kδ inhibitor. | |||
T15398 | GNE-0946 | Others | |
GNE-0946 is a potent and selective agonist of RORγ (EC50: 4 nM for HEK-293 cell). | |||
T26621 | AMP-579 | RPR100579,RPR 100579,AMP 579,RPR-100579 | |
AMP-579 is an adenosine A1 receptor agonist. AMP-579 also acts as a A2b-adenosine receptor agonist in human 293 cells and rabbit hearts. | |||
T15404 | GNE-6468 | Others | |
GNE-6468 is a potent and selective agonist of RORγ(RORc) (EC50: 13 nM for HEK-293 cell). | |||
T10271 | AHR antagonist 4 | Others | |
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects. | |||
T25109 | ARN-6039 | ARN 6039,ARN6039 | |
ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HE... | |||
T41214 | (S)-BAY-293 | BAY 294,BAY 293 Negative Control | Ras |
(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers. |